Characterization of cancer cell membranes

Discovery of new targets for cancer therapy

We identify cancer-specific features such as:

• Membrane lipids: e.g. phosphatidylserine (PS) exposed on cancer cell membranes, alterations in sphingolipid or other lipid patterns

• Membrane proteins and lipid metabolism: lipid-metabolizing enzymes

The biggest problem in cancer therapy is the lack of a cancer-specific target for the applied cytostatic drugs besides excessive growth. We investigate the differences in the outer surface of cell membranes of cell lines, primary cells and patient-derived cells of melanoma, glioblastoma, rhabdomyosarcoma, renal, pancreatic, colon and prostate cancer of predominantly human, but also murine, equine and canine origin.

Publication:

^{Riedl et al, 2011,doi: 10.1016/j.bbamem.2011.07.026.}